Promising Findings from MSK Researchers
Researchers at Memorial Sloan Kettering Cancer Center (MSK) have published promising findings in the journal Immunity. Their study suggests that fasting may improve the body’s natural defenses against cancer.
Tumors and Nutrient Deprivation
“Tumors are very hungry,” said Joseph Sun, an immunologist and the study’s co-corresponding author. “They take up essential nutrients, creating a hostile environment often rich in lipids that are detrimental to most immune cells. What we show here is that fasting reprograms these natural killer cells to better survive in this suppressive environment.”
Impact of Fasting on NK Cells
The study focused on how fasting impacts natural killer (NK) cells, a type of immune cell crucial in fighting tumors. The researchers found that fasting for 24 hours, repeated twice a week, enhanced the ability of NK cells to target as well as destroy cancer cells in mice.
Metabolic Reprogramming
This effect is linked to how fasting reprograms the metabolism of NK cells, allowing them to function more effectively in the harsh tumor environment. Tumors are known to gobble up nutrients, leaving surrounding healthy cells starved. Fasting appears to switch NK cells to a metabolic state that better equips them to survive as well as thrive in this nutrient-poor environment.
Potential for Complementary Cancer Therapy
The study’s findings offer exciting possibilities for developing fasting protocols as a complementary therapy alongside traditional cancer treatments. However, it’s important to note that this research was conducted in mice, and further studies are needed to determine if similar effects occur in humans. If you’re interested in exploring fasting for health benefits, consult a doctor or registered dietitian first.
